Formulation Analyses of Off-the-shelf Pharmaceuticals

The PDF-4/Organics database is an ongoing annually updated collaboration between the International Centre for Diffraction Data (ICDD) and the Cambridge Crystallographic Data Centre (CCDC). This database combines data taken from both powder diffraction experiments and data collected from single crystal crystallographic determinations that can be calculated into a reference powder pattern. The database also contains bibliographic references for sample preparation, data collection, and associated physical property measurements. In total, the database contain 218,194 entry sets with 416,554 references citations from 931 journals. Data from all sources are standardized, statistically analyzed, and extensively reviewed and edited prior to publication. In the 2004 release, several inorganic salts and excipients were also added to the database to aid those doing formulation analysis in law enforcement and pharmaceutical analyses. The inorganic additions included data from collaborations between the ICDD, FIZ-Karlsruhe and the National Institute of Standards and Technology (NIST). Therefore the database represents select data from multiple sources all combined for the purpose of unknown identification.